Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds
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چکیده
منابع مشابه
Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds
Drugs currently available for leishmaniasis treatment often show parasite resistance, highly toxic side effects and prohibitive costs commonly incompatible with patients from the tropical endemic countries. In this sense, there is an urgent need for new drugs as a treatment solution for this neglected disease. Here we show the development and implementation of an automated high-throughput viabi...
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Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that >300,000 cases per annum are reported in USA alone. A total of 10%-20% of patients who have been treated with antibiotic therapy report the recrudescence of symptoms, such as muscle and joint pain, psychosocial and cognitive difficulties, and generalized fatigue. This condition is referred to as po...
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The discovery of new therapeutic options against Trypanosoma cruzi, the causative agent of Chagas disease, stands as a fundamental need. Currently, there are only two drugs available to treat this neglected disease, which represents a major public health problem in Latin America. Both available therapies, benznidazole and nifurtimox, have significant toxic side effects and their efficacy agains...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2010
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0000675